Investigating organelle dysfunctions in Alzheimer's disease
Alzheimer's Disease Organelle Proteome Task (ADOPT)-pilot phase
This study is looking at how problems with tiny parts of our cells, called mitochondria and lysosomes, might play a role in Alzheimer's disease, and it's for anyone interested in understanding more about how this condition develops.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11035435 on NIH RePORTER |
What this research studies
This research focuses on understanding how dysfunctions in cellular organelles, particularly mitochondria and lysosomes, contribute to Alzheimer's disease and related dementias. An interdisciplinary team will use a genetic tagging approach to isolate lysosomes from neurons in mouse models of Alzheimer's. They will then employ mass spectrometry to analyze the organelle proteome, measuring protein levels and modifications to gain insights into organelle function during disease progression. This comprehensive approach aims to uncover new mechanisms underlying Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Alzheimer's disease or related dementias, as well as those at risk due to genetic factors.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promise in studying organelle dysfunctions in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Wang, Biao — University of California, San Francisco
- Study coordinator: Wang, Biao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.