Investigating organelle dysfunctions in Alzheimer's disease
Official title: Alzheimer's Disease Organelle Proteome Task (ADOPT)-pilot phase
Funded at University of California, San Francisco · NIH-11035435 · Data updated 2026-11-12
This study is looking at how problems with tiny parts of our cells, called mitochondria and lysosomes, might play a role in Alzheimer's disease, and it's for anyone interested in understanding more about how this condition develops.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $328,000 |
| NIH project number | 1R03AG091095-01 |
| Project ID | NIH-11035435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Alzheimer's disease or related dementias, as well as those at risk due to genetic factors.
✕Less likely to help
Patients with non-neurodegenerative conditions or those not affected by Alzheimer's disease or related dementias may not benefit from this research.
What this research studies
This research focuses on understanding how dysfunctions in cellular organelles, particularly mitochondria and lysosomes, contribute to Alzheimer's disease and related dementias. An interdisciplinary team will use a genetic tagging approach to isolate lysosomes from neurons in mouse models of Alzheimer's. They will then employ mass spectrometry to analyze the organelle proteome, measuring protein levels and modifications to gain insights into organelle function during disease progression. This comprehensive approach aims to uncover new mechanisms underlying Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in studying organelle dysfunctions in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Wang, Biao — University of California, San Francisco
- Study coordinator: Wang, Biao
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.