Investigating nighttime blood pressure issues in children with kidney disease
Official title: Kids: Nocturnal Investigation into Glomerular Disease, Hypertension, and Transcriptomics (kNIGHT)
Funded at Feinstein Institute for Medical Research · NIH-11032011 · Data updated 2026-11-12
This study is looking at kids with kidney problems that cause protein in their urine, to see how their nighttime blood pressure affects their heart health over time, and it hopes to find ways to predict and manage these issues better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | March 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $665,742 |
| NIH project number | 5R01HL162912-03 |
| Project ID | NIH-11032011 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with proteinuric glomerulopathies who may experience nighttime blood pressure dysregulation.
✕Less likely to help
Patients without kidney disease or those who do not experience nocturnal blood pressure issues may not benefit from this research.
What this research studies
This research focuses on children with proteinuric glomerulopathies, who are at a higher risk for cardiovascular disease due to nighttime blood pressure problems. The study aims to understand how these nighttime blood pressure issues relate to heart health over time and to identify clinical and molecular markers that could predict these problems. By monitoring blood pressure patterns and analyzing biological data, the research seeks to uncover important links between kidney health and cardiovascular risks in children. This could lead to better management strategies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for children with kidney disease, potentially reducing their risk of cardiovascular complications.
How similar studies have gone: Previous research has shown that understanding blood pressure patterns in children with kidney disease can lead to significant insights, suggesting that this approach may yield valuable results.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Sethna, Christine B — Feinstein Institute for Medical Research
- Study coordinator: Sethna, Christine B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.