Investigating nicorandil for treating aging-related brain changes
Safety and modulation of ABCC9 pathways by nicorandil for the treatment of hippocampal sclerosis of aging (SMArTâHS)
This study is looking at whether a medication called nicorandil is safe and helpful for older adults with hippocampal sclerosis of aging, a condition that can be mistaken for Alzheimer's, and it involves 62 participants over 75 years old who will take either the medication or a placebo for about two years.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11041026 on NIH RePORTER |
What this research studies
This research is focused on testing the safety and effectiveness of a medication called nicorandil for treating hippocampal sclerosis of aging, a condition that affects many elderly individuals and is often misdiagnosed as Alzheimer's disease. The study will involve a clinical trial with 62 participants aged over 75, who will receive either nicorandil or a placebo over a 96-week period. Researchers will monitor neurodegenerative biomarkers and assess the safety of the treatment in this population. The goal is to find a potential therapy for a condition that currently has no validated treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals over 75 years old who show signs of hippocampal sclerosis of aging.
Not a fit: Patients who are younger than 75 or do not have the specific biomarkers associated with hippocampal sclerosis of aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for elderly patients suffering from hippocampal sclerosis of aging.
How similar studies have performed: While this approach is novel in targeting hippocampal sclerosis of aging, previous studies have shown promise in using similar pharmacological mechanisms for other age-related conditions.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Jicha, Gregory a — University of Kentucky
- Study coordinator: Jicha, Gregory a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.