Investigating new ways to treat pain without opioids
Peripheral and Central Pathways of α3 Glycine Receptors as Non-Opioid Molecular Targets to Treat Pain
This study is looking for new ways to help people with chronic pain feel better without using opioids, by finding a special spot on certain receptors in the nervous system that can provide relief safely.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11039971 on NIH RePORTER |
What this research studies
This research focuses on developing non-opioid treatments for chronic pain by enhancing the activity of glycine receptors in the nervous system. Researchers are exploring a novel drug binding site that can provide pain relief without the risk of addiction associated with traditional pain medications. By using advanced techniques like structural biology and electrophysiology, they aim to identify compounds that can effectively modulate these receptors. The goal is to create a new class of analgesics that can alleviate pain while minimizing side effects.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing chronic pain who are seeking alternative treatments to opioids.
Not a fit: Patients who do not experience chronic pain or have conditions unrelated to pain management may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer pain management options for patients suffering from chronic pain conditions.
How similar studies have performed: Previous research has shown promise in targeting glycine receptors for pain relief, indicating a potential for success with this novel approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Xu, Yan — University of Pittsburgh at Pittsburgh
- Study coordinator: Xu, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.