Investigating new ways to treat chronic pain by targeting specific receptors in cells.
Official title: Targeting Endosomal Receptors for Treatment of Chronic Pain
Funded at New York University · NIH-10265663 · Data updated 2026-11-12
This study is looking at how specific receptors in nerve cells might play a role in chronic pain, with the hope of finding new medications that can help relieve pain more effectively and with fewer side effects for people who suffer from long-lasting pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $795,324 |
| NIH project number | 4R01DE029951-02 |
| Project ID | NIH-10265663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic pain conditions who have not found relief with current treatments.
✕Less likely to help
Patients with acute pain or those who do not experience chronic pain may not benefit from this research.
What this research studies
This research focuses on understanding how certain receptors in nerve cells contribute to chronic pain. It aims to explore the role of endosomal G protein-coupled receptors (eGPCRs) in pain signaling, which may lead to the development of new medications that can effectively relieve pain with fewer side effects. By studying the mechanisms of these receptors, the research seeks to identify potential drug targets that could improve pain management for patients suffering from chronic conditions. The approach involves advanced techniques in biophysics and imaging to observe how these receptors function within cells.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain relief options for patients with chronic pain conditions.
How similar studies have gone: Previous research has shown promise in targeting G protein-coupled receptors for pain management, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Bunnett, Nigel W — New York University
- Study coordinator: Bunnett, Nigel W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.