Investigating new ways to help the heart heal from inflammation-related damage
Official title: Novel regulators of macrophage function to repair sterile inflammation-induced heart injury
Funded at University of Cincinnati · NIH-11046610 · Data updated 2026-11-12
This study is looking at how special immune cells can be adjusted to help the heart heal better after injury, especially for people with conditions like type-2 diabetes, with the hope of finding new ways to improve heart health and recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $400,672 |
| NIH project number | 5R35GM149538-03 |
| Project ID | NIH-11046610 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with heart injury due to inflammation, particularly those with conditions like type-2 diabetes.
✕Less likely to help
Patients with heart conditions unrelated to inflammation or those who do not have any form of heart injury may not benefit from this research.
What this research studies
This research focuses on understanding how certain immune cells, specifically macrophages, can be regulated to improve heart function after injury caused by inflammation. The team will explore novel proteins that play a role in clearing dead cells and restoring heart health, particularly in cases of heart injury related to conditions like type-2 diabetes. By studying these mechanisms, the research aims to identify new therapeutic targets that could lead to better treatments for heart failure. Patients may benefit from insights gained into how to enhance heart recovery and function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart recovery and function for patients suffering from inflammation-related heart injuries.
How similar studies have gone: While there have been challenges in previous trials targeting inflammation in heart failure, this research aims to explore novel mediators, making it a potentially innovative approach.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Fan, Guo-Chang — University of Cincinnati
- Study coordinator: Fan, Guo-Chang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.