Investigating new treatments to cure HIV in infant macaques
Official title: Virus and Host Directed Immunotherapies for Cure in SHIV-infected Infant Macaques
Funded at Emory University · NIH-11201528 · Data updated 2026-11-12
This study is looking at new ways to use special antibodies to help fight HIV in baby monkeys, which could help us find better treatments for human infants with the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 10, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,332,155 |
| NIH project number | 1R01AI192330-01 |
| Project ID | NIH-11201528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants who are newly infected with HIV, particularly those who may have contracted the virus through breastfeeding.
✕Less likely to help
Patients who are not infants or those who are not newly infected with HIV may not benefit from this research.
What this research studies
This research focuses on developing innovative immunotherapy strategies to cure HIV in infant macaques, which can provide insights applicable to human infants. The study aims to optimize the use of broadly neutralizing antibodies (bNAbs) by testing various methods to enhance their effectiveness against the virus. Researchers will explore how to reactivate the virus in infected cells, stimulate the immune response, and improve the binding of bNAbs to infected cells. By analyzing these approaches, the research seeks to limit the viral reservoir and potentially achieve ART-free control of the virus.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments that help cure HIV in infants, significantly improving their health outcomes.
How similar studies have gone: While there have been encouraging results with similar immunotherapy approaches, this specific optimization strategy in infant macaques is novel and has not been extensively tested.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Chahroudi, Ann M — Emory University
- Study coordinator: Chahroudi, Ann M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.