Investigating new treatments for stroke by targeting harmful protein aggregation
Official title: Novel Anti-Stroke Agents Targeting Toxic Protein Aggregation
Funded at VA San Diego Healthcare System · NIH-10852817 · Data updated 2026-11-12
This study is looking at how messed-up proteins in the brain can cause more damage after a stroke, with the goal of finding new treatments to help stroke patients recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| NIH project number | 5I01BX005814-02 |
| Project ID | NIH-10852817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke or are at high risk for stroke.
✕Less likely to help
Patients who have not had a stroke or those with conditions unrelated to stroke may not benefit from this research.
What this research studies
This research focuses on understanding how misfolded proteins contribute to brain injury after a stroke. It examines the process of protein synthesis and how certain proteins can aggregate in neurons, leading to cell death. By studying these mechanisms, the research aims to develop novel anti-stroke agents that could improve recovery outcomes for stroke patients. The approach involves both laboratory experiments and analysis of post-stroke brain tissue to identify potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and outcomes for stroke patients.
How similar studies have gone: Previous research has shown promising results in targeting protein aggregation in other neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Hu, Bingren — VA San Diego Healthcare System
- Study coordinator: Hu, Bingren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.