Investigating new treatments for small cell lung cancer using Jumonji inhibitors
Jumonji KDM4A drives targetable oncogenic programs in small cell lung cancer
This study is looking at small cell lung cancer and how certain enzymes might make it tougher to treat, with the goal of finding new ways to help patients who haven't had success with standard treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11112559 on NIH RePORTER |
What this research studies
This research focuses on small cell lung cancer (SCLC), a type of cancer known for its rapid development of drug resistance. The team aims to explore the role of Jumonji lysine demethylases, which are enzymes that may contribute to the aggressive nature of SCLC. By using specialized inhibitors that target these enzymes, the researchers hope to develop new therapeutic strategies that could be effective even in cases where traditional treatments have failed. Patients may benefit from innovative treatment options that could improve outcomes for this challenging cancer type.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with small cell lung cancer, especially those experiencing drug resistance.
Not a fit: Patients with other types of lung cancer or those who do not have small cell lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for patients with small cell lung cancer, particularly those who have not responded to existing therapies.
How similar studies have performed: While the approach of targeting Jumonji demethylases in cancer treatment is promising, it is still considered a novel strategy with limited prior success in clinical settings.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Martinez, Elisabeth D — Ut Southwestern Medical Center
- Study coordinator: Martinez, Elisabeth D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.