Investigating new treatments for ovarian cancer to improve patient survival
Official title: HCC Ovarian Cancer SPORE
Funded at University of Pittsburgh at Pittsburgh · NIH-10925273 · Data updated 2026-11-12
This study is looking at new treatments for ovarian cancer to help women who struggle with current therapies, and it aims to find out which patients will benefit the most from these new options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,165,016 |
| NIH project number | 5P50CA272218-02 |
| Project ID | NIH-10925273 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with ovarian cancer who are experiencing resistance to standard therapies.
✕Less likely to help
Patients with early-stage ovarian cancer who have not yet undergone treatment may not benefit from this research.
What this research studies
This research focuses on ovarian cancer, a condition with a high mortality rate among women. It aims to address the challenges of treatment resistance that patients often face with current therapies like chemotherapy and PARP inhibitors. The project includes clinical trials testing new agents designed to overcome these resistances, while also identifying which patients are most likely to benefit from these therapies. By combining innovative treatment approaches, the research seeks to enhance patient outcomes and survival rates.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for ovarian cancer, improving survival rates for patients.
How similar studies have gone: Previous research has shown promise in using targeted therapies to overcome treatment resistance in various cancers, suggesting potential success for this approach.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Buckanovich, Ronald J — University of Pittsburgh at Pittsburgh
- Study coordinator: Buckanovich, Ronald J
Related research
Other NIH-funded projects on the same topics.
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Understanding the experience of ovarian cancer after diagnosis to improve survivorship
This NIH grant funds a mixed-methods study to better understand physical and emotional challenges faced by ovarian cancer survivors and how supportive care can help them live better after diagnosis.
-
Targeting quiescent ovarian cancer cells to overcome chemotherapy resistance
A study focusing on why some ovarian cancer cells pause dividing and resist chemotherapy, with the goal of finding new treatment targets for relapsed disease.
-
Photodynamic lipids to boost chemotherapy for metastatic ovarian cancer
A patient-friendly approach tests a light-activated method to make ovarian cancer metastases more sensitive to chemotherapy.
-
Integrated framework to validate and quantify proteoforms in patient-derived ovarian cancer cells
A collaboration will combine advanced top-down proteomics with a new computational method to precisely identify and measure intact proteoforms in tiny samples from ovarian cancer cells.
-
Overcoming platinum resistance in ovarian cancer: finding biomarkers and new targets
Researchers are looking for new biomarkers and targets to help prevent or overcome platinum resistance in high‑risk ovarian cancer so patients have better chances at long-term control.
-
Alternative NF-kB activation after chemotherapy in ovarian cancer
This grant studies how ovarian cancer might come back after chemotherapy by looking at specific signaling pathways in cancer cells and the tumor environment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.