Investigating new treatments for inflammatory bowel disease using targeted protein degradation.
Official title: PROTACs Regulating HIF in Mucosal Inflammation
Funded at University of Colorado Denver · NIH-11110728 · Data updated 2026-11-12
This study is looking at how low oxygen levels in the gut affect people with inflammatory bowel disease (like Crohn's and ulcerative colitis) and is testing new ways to improve treatments by targeting specific proteins, which could help you manage your condition better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | April 11, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $151,643 |
| NIH project number | 1K01DK143211-01 |
| Project ID | NIH-11110728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
✕Less likely to help
Patients with other gastrointestinal disorders not classified as inflammatory bowel disease may not receive benefits from this research.
What this research studies
This research focuses on inflammatory bowel disease (IBD), which includes conditions like Crohn's disease and ulcerative colitis that currently have limited treatment options. The study explores how hypoxia affects intestinal health and how specific proteins can be targeted for degradation to stabilize important transcription factors that help maintain intestinal balance. By using innovative compounds called PROTACs, the research aims to enhance the effectiveness of treatments by improving the specificity and potency of these interventions. Patients may benefit from new therapeutic strategies that could lead to better management of their condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from inflammatory bowel disease.
How similar studies have gone: While the use of PROTACs is a relatively novel approach, preliminary studies have shown promise in targeting specific proteins for therapeutic benefits.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Ornelas Sanchez, Alfredo — University of Colorado Denver
- Study coordinator: Ornelas Sanchez, Alfredo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.