Investigating new treatments for dry eye disease
Official title: Human Ocular Surface Electrophysiology
Funded at University of California, San Francisco · NIH-11015055 · Data updated 2026-11-12
This study is looking for new ways to help people with dry eye disease feel better by improving tear production, using lab techniques and tests with real people to find effective treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $219,343 |
| NIH project number | 5K08EY033859-03 |
| Project ID | NIH-11015055 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who experience symptoms of dry eye disease.
✕Less likely to help
Patients with conditions unrelated to dry eye disease or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on developing new therapies for dry eye disease (DED), a condition that affects tear film stability and causes discomfort. The project involves training in ocular surface electrophysiology and using human corneal epithelial cell cultures to explore how to enhance tear fluid secretion. By employing innovative methods to measure electrical potentials in the ocular surface, the research aims to identify and advance drug candidates that could improve the management of DED. The work will also include clinical studies involving human subjects to validate findings from laboratory models.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for dry eye disease, improving the quality of life for patients suffering from this condition.
How similar studies have gone: Previous research has shown promise in using electrophysiological methods to study ocular surface conditions, indicating potential for success in this novel approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Pasricha, Neel Dave — University of California, San Francisco
- Study coordinator: Pasricha, Neel Dave
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.