Investigating new treatments for carbon monoxide poisoning using blood cells and mitochondrial therapy.
Official title: The Use of Blood Cells and Optical Cerebral Complex IV Redox States in a Porcine Model of CO Poisoning with Evaluation of Mitochondrial Therapy
Funded at University of Pennsylvania · NIH-10917355 · Data updated 2026-11-12
This study is looking at how carbon monoxide poisoning affects the energy-making parts of your cells and is testing a new treatment that might help reduce the damage caused by the poisoning, with the goal of finding better ways to diagnose and treat people who have been affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $697,893 |
| NIH project number | 5R01HL166592-02 |
| Project ID | NIH-10917355 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced carbon monoxide poisoning, particularly those with severe symptoms or complications.
✕Less likely to help
Patients who have not been exposed to carbon monoxide or those with unrelated medical conditions may not benefit from this research.
What this research studies
This research focuses on understanding how carbon monoxide (CO) poisoning affects mitochondrial function in the body, which is crucial for developing new diagnostics and treatments. The study uses a porcine model to explore the effectiveness of a novel therapy involving a succinate prodrug that may help mitigate the damage caused by CO poisoning. By examining blood cells and their response to CO exposure, the research aims to identify better biomarkers for assessing the severity of poisoning and the effectiveness of treatments. This work is particularly important as current therapies have limitations and many patients suffer long-term cognitive impairments after CO exposure.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for patients suffering from carbon monoxide poisoning.
How similar studies have gone: While there has been research on CO poisoning, this approach using mitochondrial therapy and novel biomarkers is relatively novel and untested.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Jang, David H — University of Pennsylvania
- Study coordinator: Jang, David H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.