Investigating new treatments for carbon monoxide poisoning using blood cells and mitochondrial therapy.
The Use of Blood Cells and Optical Cerebral Complex IV Redox States in a Porcine Model of CO Poisoning with Evaluation of Mitochondrial Therapy
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10917355
This study is looking at how carbon monoxide poisoning affects the energy-making parts of your cells and is testing a new treatment that might help reduce the damage caused by the poisoning, with the goal of finding better ways to diagnose and treat people who have been affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10917355 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how carbon monoxide (CO) poisoning affects mitochondrial function in the body, which is crucial for developing new diagnostics and treatments. The study uses a porcine model to explore the effectiveness of a novel therapy involving a succinate prodrug that may help mitigate the damage caused by CO poisoning. By examining blood cells and their response to CO exposure, the research aims to identify better biomarkers for assessing the severity of poisoning and the effectiveness of treatments. This work is particularly important as current therapies have limitations and many patients suffer long-term cognitive impairments after CO exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced carbon monoxide poisoning, particularly those with severe symptoms or complications.
Not a fit: Patients who have not been exposed to carbon monoxide or those with unrelated medical conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for patients suffering from carbon monoxide poisoning.
How similar studies have performed: While there has been research on CO poisoning, this approach using mitochondrial therapy and novel biomarkers is relatively novel and untested.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JANG, DAVID H — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: JANG, DAVID H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.