Investigating new treatments for breast cancer, especially triple-negative types.
Official title: SPORE in Breast Cancer
Funded at Vanderbilt University Medical Center · NIH-11192999 · Data updated 2026-11-12
This study is all about finding better ways to treat breast cancer, especially for those with triple-negative breast cancer, by using new ideas and tests to personalize treatments based on what works best for each patient.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $896,275 |
| NIH project number | 3P50CA098131-21S2 |
| Project ID | NIH-11192999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with triple-negative breast cancer or those at high risk for developing breast cancer.
✕Less likely to help
Patients with non-breast cancer conditions or those not diagnosed with breast cancer may not receive any benefit from this research.
What this research studies
This research focuses on improving outcomes for patients with breast cancer, particularly those with triple-negative breast cancer (TNBC). It involves collaborative efforts among experts to explore innovative strategies, including genomic and immune-based discoveries, to enhance treatment responses. The research also aims to utilize liquid biopsies to tailor therapies for TNBC patients, ensuring that patient perspectives are integrated throughout the process. By leveraging advanced biostatistics and bioinformatics, the study seeks to provide meaningful insights into breast cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for breast cancer patients.
How similar studies have gone: Previous research has shown promise in similar approaches targeting breast cancer, particularly in enhancing immunotherapy responses.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Pietenpol, Jennifer a — Vanderbilt University Medical Center
- Study coordinator: Pietenpol, Jennifer a
Related research
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-
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-
Genomic study to understand how genetics and epigenetics shape triple-negative breast cancer in African ancestry
This study looks at how inherited genes and gene activity affect triple-negative breast cancer in people of African ancestry to better understand why outcomes can be worse.
-
Translational breast cancer research to improve treatment options
A comprehensive program at Baylor College of Medicine is focusing on breast cancer; researchers will advance targeted therapies and biomarkers to help patients with aggressive or hard-to-treat forms.
-
Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms
A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.
-
Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans
A study aims to block two cancer-promoting pathways (IL-6 and CDK4/6) to prevent or reduce progression of triple-negative breast cancer in women veterans.
-
Gut bacteria and metabolites linked to breast density and cancer risk
A small, patient-friendly study will explore whether gut bacteria and their byproducts are connected to high breast density, which can raise cancer risk and make screening less accurate.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.