Investigating new treatments for adrenal cancer using advanced models
Targeting Kinases in Novel Preclinical Models of Adrenocortical Carcinoma
This study is looking at a tough type of adrenal cancer called adrenocortical carcinoma (ACC) to find better treatments, using new lab models that mimic the disease and help researchers understand how it works.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11118785 on NIH RePORTER |
What this research studies
This research focuses on adrenocortical carcinoma (ACC), a severe form of adrenal cancer with low survival rates. The team is developing new human cell lines and patient-derived xenograft models to better understand the disease and identify potential therapeutic targets. By analyzing genetic data, they aim to uncover the molecular mechanisms driving ACC and test new treatment options in these innovative models. This approach could lead to more effective therapies for patients suffering from this challenging cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with adrenocortical carcinoma, particularly those with genetic predispositions.
Not a fit: Patients with other types of cancer or those without a diagnosis of adrenocortical carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel and more effective treatments for patients with adrenocortical carcinoma.
How similar studies have performed: While there has been limited success in targeting pathways in adrenocortical carcinoma, the development of new models for testing treatments represents a novel approach in this field.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Kiseljakvassiliades, Katja — VA Eastern Colorado Health Care System
- Study coordinator: Kiseljakvassiliades, Katja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.