Investigating new treatment strategies for cervical cancer
Official title: Research Project Cervical Cancer
Funded at Washington University · NIH-10912702 · Data updated 2026-11-12
This study is looking at how certain immune cells in the body affect the treatment of locally advanced cervical cancer, with the goal of finding better ways to help patients respond to radiation therapy and improve their chances of recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $247,065 |
| NIH project number | 5U54CA274318-02 |
| Project ID | NIH-10912702 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with locally advanced cervical cancer who are undergoing standard treatment.
✕Less likely to help
Patients with early-stage cervical cancer or those who have already received multiple lines of treatment may not benefit from this research.
What this research studies
This research focuses on improving treatment outcomes for patients with locally advanced cervical cancer, which currently has a high failure rate with standard therapies. The study examines the role of tumor-associated macrophages in the tumor microenvironment and how they interact with cancer cells after radiation therapy. By analyzing these interactions, the research aims to identify metabolic changes that could be targeted to enhance anti-tumor immunity and improve patient responses to treatment. Patients may be involved in trials that explore new therapeutic approaches based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for cervical cancer, potentially reducing recurrence rates and improving survival.
How similar studies have gone: Previous research has shown promising results in targeting tumor-associated macrophages to enhance cancer treatment, suggesting that this approach may be effective.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Schwarz, Julie Kristina — Washington University
- Study coordinator: Schwarz, Julie Kristina
Related research
Other NIH-funded projects on the same topics.
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Community and digital tools to reduce HPV and cervical cancer burden
A nurse or health team will test a community-based, digital strategy to help girls and young women, especially in rural areas, get HPV vaccination and cervical cancer prevention services.
-
Community and digital tools to reduce HPV and cervical cancer in women with HIV
A community- and digital-technology program aims to help girls and young women, including those with HIV, get more HPV vaccination and cervical cancer prevention services.
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mSaada: a mobile tool to boost cervical cancer screening in western Kenya
A mobile app helps community health volunteers manage cervical cancer screening tasks and follow-up for women in low-resource areas.
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Globally useful predictor for cervical cancer treatment response
This project aims to develop a simple predictive signature to personalize treatment for locally advanced cervical cancer using easy tests and imaging.
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HPV self-collection in HIV care to screen for cervical cancer in Ethiopia
A patient-centered program tests a simple HPV self-collection approach within HIV clinics in Ethiopia to help detect cervical cancer earlier.
-
Hybrid approach to boost cervical cancer screening in Uganda
A tested, community-driven program helps Ugandan women encourage their peers to get free VIA cervical cancer screening.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.