Investigating new therapies to protect the brain during stroke treatment
Official title: Augusta SPAN 2
Funded at Augusta University · NIH-11001215 · Data updated 2026-11-12
This study is looking for better ways to help people who have had a stroke by testing new treatments that could work alongside current therapies to improve blood flow and protect the brain, with the goal of finding the best options for future use in patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | February 15, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $554,399 |
| NIH project number | 5U01NS130590-03 |
| Project ID | NIH-11001215 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an acute ischemic stroke and are undergoing thrombolysis or endovascular thrombectomy.
✕Less likely to help
Patients who have not experienced a stroke or those with other types of strokes may not benefit from this research.
What this research studies
This research focuses on improving outcomes for patients with acute ischemic stroke by testing new adjunctive therapies alongside existing treatments like thrombolysis and endovascular thrombectomy. The study aims to enhance collateral blood flow and provide neuroprotection, which are critical for recovery. Using a multi-site preclinical randomized clinical trial network, the research will evaluate up to eight selected drugs or interventions in rodent models to identify the most effective cerebroprotective agents for future clinical trials. This approach seeks to bridge the gap between laboratory findings and patient care.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce disability in stroke patients after existing therapies.
How similar studies have gone: Previous phases of the SPAN network have shown success in establishing feasibility and protocol adherence, indicating a promising approach for this type of research.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Hess, David C. — Augusta University
- Study coordinator: Hess, David C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.