Investigating new models of intestinal cancer using advanced genetic techniques
Polymerase epsilon-based mouse and derived organoid models of intestinal cancer
This study is working on new ways to create mouse and organoid models that mimic intestinal cancer to help us learn more about how this type of cancer behaves and responds to treatments, which could lead to better options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10919176 on NIH RePORTER |
What this research studies
This research focuses on developing innovative mouse and organoid models to better understand intestinal cancer, which is a leading cause of cancer deaths. The approach involves creating genetically engineered models that mimic the high mutation rates found in human cancers, allowing for a more accurate study of tumor behavior and response to therapies. By utilizing advanced genetic tools, the research aims to uncover critical aspects of tumor biology that have been overlooked in traditional models. Patients may benefit from insights gained that could lead to improved treatment strategies for intestinal cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals diagnosed with intestinal cancer or those at high risk for developing it.
Not a fit: Patients with cancers unrelated to the intestines or those who do not have a genetic predisposition to intestinal cancer may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for intestinal cancer by providing a better understanding of tumor biology.
How similar studies have performed: While there have been successful studies using genetic models in cancer research, this specific approach to modeling intestinal cancer with high mutation rates is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Castrillon, Diego H — Ut Southwestern Medical Center
- Study coordinator: Castrillon, Diego H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.