Investigating new models of dementia related to TDP-43 function
Official title: Characterizing novel Mixed Etiology Dementia models compromised for TDP-43 function
Funded at Johns Hopkins University · NIH-11016937 · Data updated 2026-11-12
This study is looking at how a specific protein called TDP-43 affects memory and brain health in people with Alzheimer’s and related dementias, hoping to find new ways to help improve treatments for those living with these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 15, 2023 |
| Project end | October 14, 2026 |
| Funding year | 2025 |
| Award (this year) | $42,574 |
| NIH project number | 5F31NS135935-02 |
| Project ID | NIH-11016937 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals diagnosed with Alzheimer’s Disease or related dementias, particularly those exhibiting symptoms associated with TDP-43 pathology.
✕Less likely to help
Patients with dementia types that do not involve TDP-43 pathology may not receive benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind Alzheimer’s Disease (AD) and related dementias (ADRDs), particularly the role of TDP-43 pathology, which affects cognitive decline and brain atrophy. By developing models that combine traditional amyloid-beta and tau pathologies with TDP-43 pathology, the research aims to mimic the complexities of human dementia. The approach involves studying how the loss of TDP-43 nuclear function contributes to neuron loss and cognitive impairments, which is crucial for identifying potential therapeutic targets. Patients may benefit from insights gained into the molecular mechanisms of dementia, leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from Alzheimer’s Disease and related dementias.
How similar studies have gone: Previous studies have shown success in understanding dementia mechanisms, but this specific approach focusing on mixed etiology models is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Burns, Grace D — Johns Hopkins University
- Study coordinator: Burns, Grace D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.