Investigating new methods to improve sleep in people with obstructive sleep apnea.
Project 2
This study is looking for better ways to help people with obstructive sleep apnea sleep well without waking up due to breathing problems, by exploring how certain brain cells react to carbon dioxide levels.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10897854 on NIH RePORTER |
What this research studies
This research focuses on individuals with obstructive sleep apnea (OSA), a condition where airflow obstruction leads to disrupted sleep and daytime sleepiness. The study aims to explore new methods that can maintain sleep without compromising ventilation, addressing a significant gap in current treatments like CPAP. By examining specific neurons in the brain that trigger awakenings in response to increased carbon dioxide levels, the researchers hope to find ways to prevent these awakenings while still ensuring proper breathing. This could lead to improved sleep quality for patients suffering from OSA.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with obstructive sleep apnea who experience frequent awakenings during sleep.
Not a fit: Patients who do not have obstructive sleep apnea or those whose sleep disturbances are caused by other conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly enhance the quality of sleep for patients with obstructive sleep apnea, reducing daytime sleepiness and improving overall well-being.
How similar studies have performed: Previous research has shown promising results in targeting specific neurons to manage sleep disruptions, indicating potential for success in this novel approach.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Scammell, Thomas E — Beth Israel Deaconess Medical Center
- Study coordinator: Scammell, Thomas E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.