Investigating new lipid mediators to prevent aortic aneurysms and ruptures
Novel specialized pro-resolving lipid mediators in resolution of aortic aneurysms and rupture
This study is looking at how certain natural substances from omega-3 fatty acids might help prevent dangerous problems with the abdominal aorta, like aneurysms, by promoting healing and improving the immune response, and it's for anyone interested in new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10645097 on NIH RePORTER |
What this research studies
This research focuses on understanding how specialized pro-resolving mediators (SPMs), derived from omega-3 fatty acids, can help prevent the formation and rupture of abdominal aortic aneurysms (AAA). By analyzing these lipid mediators in human patients and using animal models, the researchers aim to uncover the mechanisms by which SPMs like Resolvin D1 and Maresin 1 can modulate immune responses and promote healing in the aorta. The study employs advanced techniques such as liquid chromatography and mass spectrometry to measure and characterize these mediators, potentially leading to new therapeutic strategies for AAA.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with abdominal aortic aneurysms or those at high risk for developing them.
Not a fit: Patients with aortic aneurysms that are already in advanced stages or those who have contraindications to omega-3 fatty acid treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of aortic aneurysms and their life-threatening ruptures.
How similar studies have performed: Previous research has shown promising results with similar approaches using specialized pro-resolving mediators in other inflammatory conditions, suggesting potential for success in this area as well.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Upchurch, Gilbert Rivers — University of Florida
- Study coordinator: Upchurch, Gilbert Rivers
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.