Investigating new influenza vaccines for older adults
A deep longitudinal analysis of next generation influenza vaccines in older adults
This study is looking at why older adults don’t respond as well to regular flu shots and whether new types of vaccines can help boost their immunity, so if you're 65 or older, you could help us find better ways to protect people like you from the flu!
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-11001470 on NIH RePORTER |
What this research studies
This research focuses on understanding why older adults have a limited response to traditional influenza vaccines and whether next-generation vaccines can improve their immunity. By establishing a cohort of healthy older adults aged 65 and above, participants will receive three different influenza vaccines over three consecutive years. The study aims to analyze the immune responses and mechanisms that affect vaccine effectiveness in this age group. Through this approach, researchers hope to uncover insights that could lead to better vaccination strategies for older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are healthy adults aged 65 years and older who are willing to participate in a longitudinal vaccination program.
Not a fit: Patients who are younger than 65 years or those with significant health issues that prevent them from receiving vaccinations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective influenza vaccines specifically designed for older adults, reducing illness and mortality rates in this vulnerable population.
How similar studies have performed: Previous research has shown that understanding immune responses in older adults can lead to improved vaccine formulations, suggesting potential for success in this novel approach.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Ucar, Duygu — Jackson Laboratory
- Study coordinator: Ucar, Duygu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.