Investigating new drugs for Alzheimer's disease targeting a specific brain receptor
Subtype-selective NMDA ligands for Alzheimer's Disease
This study is working on a new imaging tool to help us see how a specific part of the brain related to Alzheimer's disease works, which could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11075243 on NIH RePORTER |
What this research studies
This research focuses on developing a novel PET ligand that targets the GluN2B subunit of the N-Methyl-D-aspartic acid receptor, which is crucial in understanding and treating Alzheimer's disease and related dementias. By using advanced imaging techniques, the study aims to quantify the distribution and engagement of this receptor in living brains, providing insights that were previously unattainable. The goal is to create a more effective therapeutic approach by improving drug discovery processes for Alzheimer's treatments. Patients may benefit from enhanced understanding and potential new therapies targeting this specific receptor.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Alzheimer's disease, improving patient outcomes and quality of life.
How similar studies have performed: While there have been attempts to target the GluN2B subunit, this specific approach using a novel PET ligand is relatively untested and aims to overcome previous limitations.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Liang, Steven H — Emory University
- Study coordinator: Liang, Steven H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.