Investigating new drug targets to control blood flow in newborns
Pharmacological Validation of Vascular KATP Channels for Modulating Ductus Arteriosus Tone
This study is looking for better ways to help newborns whose important artery, called the ductus arteriosus, doesn't close properly after birth, by exploring new medications that could work more safely and effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10657531 on NIH RePORTER |
What this research studies
This research focuses on the ductus arteriosus (DA), a crucial fetal artery that needs to close after birth for proper lung function. The study aims to identify and validate new pharmacological targets, specifically vascular KATP channels, to effectively manage cases where the DA remains open (persistent patent ductus arteriosus, PDA). Current treatments are often ineffective or have significant side effects, so this research seeks to develop safer and more targeted drug therapies. By understanding how these channels work, the goal is to create better options for newborns who need help with DA closure.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns diagnosed with persistent patent ductus arteriosus who require medical intervention.
Not a fit: Patients who do not have a patent ductus arteriosus or are older children and adults will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer medications for managing persistent patent ductus arteriosus in newborns.
How similar studies have performed: While the approach of targeting KATP channels is promising, it is relatively novel and has not been extensively tested in this specific context.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Denton, Jerod S. — Vanderbilt University Medical Center
- Study coordinator: Denton, Jerod S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.