Investigating new brain stimulation techniques to treat depression
Ascertaining Neurocircuitry to Enhance Neuromodulation Development ASCEND
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10553692
This study is looking at a new treatment called magnetic seizure therapy (MST) for people with severe depression who haven't found relief from other treatments, and it hopes to find a way to help you feel better without the memory problems that can come with traditional therapies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10553692 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a safer neuromodulation treatment for patients with treatment-resistant major depressive disorder (MDD). It aims to explore the neurocognitive effects of magnetic seizure therapy (MST), which uses magnetic fields instead of electrical currents to induce seizures, potentially reducing memory-related side effects associated with traditional electroconvulsive therapy (ECT). By comparing the clinical and cognitive outcomes of MST and ECT, the study seeks to uncover the underlying neurocircuitry involved in these treatments. Patients participating in this research may contribute to a better understanding of how to effectively treat depression without the adverse cognitive effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with treatment-resistant major depressive disorder who have not responded to standard antidepressant therapies.
Not a fit: Patients with mild depression or those who have responded well to existing antidepressant treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment options for patients suffering from severe depression.
How similar studies have performed: Previous research has shown promise in using magnetic seizure therapy as a safer alternative to electroconvulsive therapy, indicating potential for success in this area.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCCLINTOCK, SHAWN M — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: MCCLINTOCK, SHAWN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.