Investigating new biomarkers for diagnosing Alzheimer's and Lewy body diseases
Pathological and cognitive correlations of real time quaking induced conversion in LBD and AD
This study is looking at a new way to help doctors better diagnose Lewy body diseases and Alzheimer's by using special tests on patient samples, which could lead to more accurate diagnoses and a clearer understanding of how these diseases progress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10851892 on NIH RePORTER |
What this research studies
This research focuses on improving the accuracy of diagnosing Lewy body diseases and Alzheimer's disease by using innovative biomarkers known as real time quaking induced conversion (RT-QuIC). The study aims to determine how well these biomarkers can predict the presence of pathological features and cognitive outcomes in patients. By analyzing biofluids from patients, researchers hope to establish a clearer connection between these biomarkers and the underlying disease processes. This could lead to more precise diagnoses and better understanding of the diseases' progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lewy body diseases or Alzheimer's disease who are undergoing cognitive assessments.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to Lewy body diseases or Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnoses for patients with Alzheimer's and Lewy body diseases.
How similar studies have performed: Previous research has shown promise in using biomarkers for diagnosing neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Coughlin, David G — University of California, San Diego
- Study coordinator: Coughlin, David G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.