Investigating neurological and mental health issues in people with HIV and substance use disorders.
Official title: CHARTER Plus: A resource for cutting-edge research on neurological function and mental health in people with HIV and substance use disorders across the lifespan
Funded at University of California, San Diego · NIH-10994651 · Data updated 2026-11-12
This study is looking to better understand how HIV affects the brain and mental health by gathering information from 500 adults, both with and without HIV, to help improve care for everyone living with the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,968,823 |
| NIH project number | 5R24MH129166-04 |
| Project ID | NIH-10994651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults living with HIV, particularly those with a history of substance use disorders, as well as individuals without HIV who are at risk for Alzheimer's disease.
✕Less likely to help
Patients who are not living with HIV and do not have risk factors for neurological or mental health disorders may not benefit from this research.
What this research studies
This research aims to enhance the CHARTER project, focusing on the neurological, cognitive, psychiatric, and substance use disorders affecting individuals with HIV across their lifespan. It will involve comprehensive assessments of a cohort of 500 adults, including those living with HIV and those without, to gather extensive data and biospecimens. The study will utilize the Research Domain Criteria framework to guide its investigations, providing valuable insights into neuroHIV and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neurological and mental health disorders in people living with HIV.
How similar studies have gone: Previous research has shown success in similar approaches, indicating the potential for significant advancements in understanding neuroHIV.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Letendre, Scott L — University of California, San Diego
- Study coordinator: Letendre, Scott L
Related research
Other NIH-funded projects on the same topics.
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CHARTER Plus: improving brain and mental health for people with HIV and substance use
This project builds a long-term resource of brain tests, mental-health measures, and stored samples to help adults with and without HIV better understand and protect their brain health across life.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.