Investigating neuroinflammation in schizophrenia using advanced MRI techniques
Validation of Diffusion Basis Spectrum Imaging of Neuroinflammation in Schizophrenia
This study is looking at how inflammation in the brain affects schizophrenia, especially in young adults, by testing a new MRI method that can spot these changes without any surgery, which could help doctors diagnose and treat the condition more effectively.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10745333 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of neuroinflammation in schizophrenia, a complex brain disorder that often begins in late adolescence. The team aims to validate a new MRI technique called Diffusion Basis Spectrum Imaging (DBSI), which can non-invasively detect neuroinflammation and related brain changes. By analyzing postmortem brain samples from young adults with schizophrenia, the researchers hope to establish a link between DBSI findings and neuroinflammation, potentially leading to earlier diagnosis and better treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 18-30 who have been diagnosed with schizophrenia.
Not a fit: Patients outside the age range of 18-30 or those without a diagnosis of schizophrenia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for schizophrenia, enhancing patient outcomes.
How similar studies have performed: Previous research has successfully validated DBSI in conditions like multiple sclerosis and Alzheimer's disease, suggesting a promising approach for schizophrenia.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Mamah, Daniel — Washington University
- Study coordinator: Mamah, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.