Investigating neuroinflammation in schizophrenia using advanced MRI techniques
Official title: Validation of Diffusion Basis Spectrum Imaging of Neuroinflammation in Schizophrenia
Funded at Washington University · NIH-10745333 · Data updated 2026-11-12
This study is looking at how inflammation in the brain affects schizophrenia, especially in young adults, by testing a new MRI method that can spot these changes without any surgery, which could help doctors diagnose and treat the condition more effectively.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | December 1, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $194,375 |
| NIH project number | 5R21MH131962-02 |
| Project ID | NIH-10745333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 18-30 who have been diagnosed with schizophrenia.
✕Less likely to help
Patients outside the age range of 18-30 or those without a diagnosis of schizophrenia may not benefit from this research.
What this research studies
This research focuses on understanding the role of neuroinflammation in schizophrenia, a complex brain disorder that often begins in late adolescence. The team aims to validate a new MRI technique called Diffusion Basis Spectrum Imaging (DBSI), which can non-invasively detect neuroinflammation and related brain changes. By analyzing postmortem brain samples from young adults with schizophrenia, the researchers hope to establish a link between DBSI findings and neuroinflammation, potentially leading to earlier diagnosis and better treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for schizophrenia, enhancing patient outcomes.
How similar studies have gone: Previous research has successfully validated DBSI in conditions like multiple sclerosis and Alzheimer's disease, suggesting a promising approach for schizophrenia.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Mamah, Daniel — Washington University
- Study coordinator: Mamah, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.