Investigating neuroinflammation and brain changes in corticobasal syndrome
Official title: Neuroinflammation, white matter integrity, AD biomarkers and pathology in corticobasal syndrome
Funded at Mayo Clinic Rochester · NIH-11052154 · Data updated 2026-11-12
This study is looking at how inflammation in the brain affects people with corticobasal syndrome (CBS) and involves tests like brain scans and blood samples to better understand these changes, so if you have CBS, you might be able to help us learn more about this condition!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $798,032 |
| NIH project number | 1R01AG087140-01A1 |
| Project ID | NIH-11052154 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with corticobasal syndrome, particularly those with either 4-repeat tauopathy or Alzheimer's disease.
✕Less likely to help
Patients who do not have corticobasal syndrome or related neurodegenerative disorders may not benefit from this research.
What this research studies
This research focuses on corticobasal syndrome (CBS), a neurodegenerative disorder that affects motor and cognitive functions. It aims to understand the biological mechanisms of neuroinflammation and how it relates to brain changes in CBS patients. The study will involve advanced imaging techniques and blood tests to assess neuroinflammation and white matter integrity in the brain. By recruiting 80 CBS patients, the research will classify them based on the presence of Alzheimer's disease biomarkers and explore the connections between these factors.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for patients with corticobasal syndrome and related neurodegenerative conditions.
How similar studies have gone: Previous research has shown promising results in understanding neuroinflammation in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Whitwell, Jennifer Louise — Mayo Clinic Rochester
- Study coordinator: Whitwell, Jennifer Louise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.