Investigating nerve connections in the spine related to low back pain
Endplate Sensory Innervations for LBP
This study is looking at how the nerves in the spine might be linked to low back pain in older adults, and by using animal models, researchers hope to find new ways to help treat this common issue.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11004727 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of sensory nerves in the spinal endplates and their connection to low back pain (LBP), particularly in older adults. By examining how aging affects these nerve connections and the surrounding bone structure, the study aims to uncover the underlying mechanisms of LBP. The researchers will utilize animal models to explore changes in nerve density and bone remodeling in the context of aging and pain. This could lead to new insights into potential treatments for LBP.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing persistent low back pain.
Not a fit: Patients with acute low back pain or those without any history of spinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for low back pain, enhancing the quality of life for many patients.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between nerve density and pain in aging populations, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Cao, Xu — Johns Hopkins University
- Study coordinator: Cao, Xu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.