Investigating nerve and immune interactions in throat issues after influenza infection
Neuroimmune interactions for laryngeal sensorimotor neuropathy in postviral influenza infection
This study is looking at how the flu virus can affect the nerves in your voice box, which might lead to problems like losing your voice or having a persistent cough, and it's using mice to figure out how these issues happen and how we might fix them.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10922743 on NIH RePORTER |
What this research studies
This research focuses on understanding how viral infections, specifically influenza, affect the nerves and immune responses in the larynx, which can lead to problems like vocal fold paralysis and chronic cough. By using a mouse model, the researchers will explore how the infection activates certain nerve cells and causes inflammation in the laryngeal tissues. They will employ advanced techniques such as imaging and genetic analysis to map the neural circuits involved and identify the specific cells that contribute to these conditions. The goal is to uncover the mechanisms behind these laryngeal issues and how they can be repaired after viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced vocal fold paralysis or chronic cough following a viral respiratory infection.
Not a fit: Patients with laryngeal issues not related to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from throat-related issues caused by viral infections.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding neuroimmune interactions in other contexts.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Foote, Alexander G — University of California, San Diego
- Study coordinator: Foote, Alexander G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.