Investigating myelination deficits related to auditory issues in Fragile X Syndrome
DEIA supplement - Myelination Deficits Underlying Auditory Issues in Fragile X Syndrome
This study is looking at how problems with brain wiring might make it hard for people with Fragile X Syndrome to process sounds, and it’s using mice to help figure out what’s going on in the brain.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma State University Stillwater NIH-funded |
| Lab location | 1 site (Stillwater, United States) |
| Project ID | NIH-10605699 on NIH RePORTER |
What this research studies
This research focuses on understanding how myelination deficits in the brain may contribute to auditory processing difficulties in individuals with Fragile X Syndrome, a genetic condition associated with autism. By studying mice with Fragile X Syndrome, researchers will examine the structure and function of auditory pathways in the brainstem, which are crucial for processing sound. The study will utilize various techniques, including anatomical assessments and non-invasive electrophysiological recordings, to gather data on myelination and auditory responses. The goal is to identify the underlying mechanisms that lead to auditory challenges in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome or related autism spectrum disorders.
Not a fit: Patients without Fragile X Syndrome or those with unrelated auditory processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for auditory processing issues in patients with Fragile X Syndrome.
How similar studies have performed: Previous research has indicated that myelination plays a critical role in auditory processing, suggesting that this approach may yield valuable insights.
Where this research is happening
Stillwater, United States
- Oklahoma State University Stillwater — Stillwater, United States (Active)
Researchers
- Principal investigator: Mccullagh, Elizabeth Anne — Oklahoma State University Stillwater
- Study coordinator: Mccullagh, Elizabeth Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.