Investigating myelin changes in Alzheimer's disease using advanced MRI techniques
Quantitative UTE MR Imaging of Myelin: Novel Biomarkers for Alzheimer's Disease
This study is looking at how damage to the protective covering of nerve fibers in the brain might happen early in Alzheimer's disease, using a special type of MRI to spot these changes before the usual signs show up, which could help doctors diagnose and track treatments for people with Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10525525 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of myelin impairment in Alzheimer's disease (AD) by utilizing a novel MRI imaging technique. It aims to identify early changes in white matter that occur before the typical signs of AD, such as amyloid plaques and neurofibrillary tangles, become apparent. By assessing myelin loss, the study seeks to improve diagnostic accuracy and monitor treatment effectiveness for patients with AD. The approach involves advanced imaging methods that provide detailed insights into brain connectivity and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those in the early stages of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease, potentially improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promise in using advanced MRI techniques to study brain changes in Alzheimer's disease, indicating that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Du, Jiang — University of California, San Diego
- Study coordinator: Du, Jiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.