Investigating muscle fibrosis in patients with cachexia
Muscle Fibrosis in Cachexia
This study is looking at how muscle scarring affects treatment responses in patients with severe muscle loss from cancer and other chronic diseases, and it aims to find better ways to help these patients feel stronger and improve their muscle function.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10895446 on NIH RePORTER |
What this research studies
This research focuses on cachexia, a condition characterized by severe muscle wasting often seen in cancer and chronic disease patients. It aims to understand how muscle fibrosis, which is the thickening and scarring of muscle tissue, affects the body's response to treatments in patients with advanced cachexia. Using a novel mouse model, the study will explore the impact of anti-inflammatory and anti-fibrosis therapies on muscle function at different stages of cachexia. By identifying the mechanisms behind muscle fibrosis, the research seeks to improve treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients or individuals with chronic diseases who are experiencing muscle wasting and cachexia.
Not a fit: Patients who do not have cachexia or muscle wasting conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients suffering from cachexia, potentially improving their quality of life and treatment outcomes.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that targeting inflammation can improve outcomes in cachexia, suggesting potential for success.
Where this research is happening
Chicago, United States
- Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab — Chicago, United States (Active)
Researchers
- Principal investigator: Roy, Ishan — Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
- Study coordinator: Roy, Ishan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.