Investigating muscle characteristics in patients with peripheral artery disease
Novel gastrocnemius muscle characteristics in peripheral artery disease patients associated with impaired functional performance
This study is looking at how certain features of the calf muscle in people with peripheral artery disease (PAD) affect their ability to walk, using muscle samples to find out more about what might be making it harder for them to move around.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10988277 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific characteristics of the gastrocnemius muscle in patients with peripheral artery disease (PAD) relate to their walking performance. By analyzing muscle biopsies stored in a biorepository, the study aims to uncover the underlying factors contributing to functional impairments in PAD. The approach involves detailed immunohistochemical analyses of muscle samples collected from various clinical trials, allowing for a comprehensive examination of muscle health in these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with peripheral artery disease, particularly those experiencing functional impairments related to walking.
Not a fit: Patients without peripheral artery disease or those who do not have functional impairments related to walking may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved interventions and therapies for patients suffering from peripheral artery disease.
How similar studies have performed: While there have been small studies indicating muscle dysfunction in PAD patients, this research aims to build on those findings with a larger and more detailed analysis, making it a novel approach.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Dupont-Versteegden, Esther E — University of Kentucky
- Study coordinator: Dupont-Versteegden, Esther E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.