Investigating mucus problems in airway diseases like chronic bronchitis and COPD
Understanding airway mucus dysfunction in population-based studies
This study is looking at how problems with mucus in your lungs can affect breathing issues like chronic bronchitis and COPD, by examining chest scans to see how mucus buildup relates to lung function and symptoms, and it aims to find out if certain lifestyle changes can help improve mucus problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10894886 on NIH RePORTER |
What this research studies
This research focuses on understanding how mucus dysfunction contributes to airway diseases such as chronic bronchitis and chronic obstructive pulmonary disease (COPD). By analyzing chest CT scans from participants in large population studies, researchers aim to identify and quantify mucus plugging in the airways. The study will explore the relationship between mucus plugging, lung function, and respiratory symptoms, as well as how certain modifiable factors may influence mucus dysfunction. This approach could provide valuable insights into the clinical significance of mucus dysfunction in respiratory health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals over 21 years old who experience chronic respiratory symptoms or have been diagnosed with chronic bronchitis or COPD.
Not a fit: Patients with acute respiratory conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for patients suffering from chronic respiratory conditions.
How similar studies have performed: Previous research has shown that understanding mucus dysfunction is critical in managing chronic respiratory diseases, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Diaz, Alejandro — Brigham and Women's Hospital
- Study coordinator: Diaz, Alejandro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.