Investigating MRI biomarkers to improve stroke prevention in patients with intracranial atherosclerotic stenosis.
Official title: CAPTIVA-MRI
Funded at Yale University · NIH-11142176 · Data updated 2026-11-12
This study is looking for ways to use MRI scans to help doctors figure out which patients with narrowed brain arteries are more likely to have another stroke, even when they’re on standard treatment, so they can get the best care possible.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,375,403 |
| NIH project number | 4UH3NS130228-02 |
| Project ID | NIH-11142176 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with symptomatic ICAS causing 70-99% stenosis.
✕Less likely to help
Patients with other types of stroke or those not diagnosed with ICAS may not benefit from this research.
What this research studies
This research focuses on patients with intracranial atherosclerotic stenosis (ICAS), a leading cause of ischemic stroke. It aims to identify MRI biomarkers that can better predict which patients are at risk for recurrent strokes despite receiving standard medical treatment. By utilizing advanced MRI techniques, the study will assess blood flow and plaque characteristics in the arteries to enhance risk stratification. Patients will be part of a larger trial comparing different medication regimens while also undergoing MRI assessments to gather critical data.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing recurrent strokes in patients with ICAS.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques to assess stroke risk, suggesting potential for success in this novel approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: De Havenon, Adam H. — Yale University
- Study coordinator: De Havenon, Adam H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.