Investigating MRI biomarkers for Huntington's disease in mouse models and humans
Advanced MRI biomarkers in HD mouse models translatable to humans: nature history and response to therapeutics
This study is looking at how we can spot changes in the brains of people at risk for Huntington's disease before they show any symptoms, using advanced MRI technology and mouse models, to help find better treatments sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10922677 on NIH RePORTER |
What this research studies
This research focuses on Huntington's disease (HD), a genetic neurodegenerative disorder, by exploring advanced MRI biomarkers that can detect changes in the brain before symptoms appear. The study utilizes mouse models to evaluate neurovascular changes and the effects of potential therapies aimed at lowering the mutant Huntingtin protein. By identifying these biomarkers, the research aims to establish reliable measures for assessing treatment efficacy in premanifest HD, potentially leading to earlier interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Huntington's disease, particularly those with a family history of the condition.
Not a fit: Patients who are already exhibiting advanced symptoms of Huntington's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and treatment options for patients with Huntington's disease, improving their quality of life.
How similar studies have performed: Previous research has shown promising results in using MRI biomarkers to assess neurovascular changes in neurodegenerative diseases, indicating potential success for this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Duan, Wenzhen — Johns Hopkins University
- Study coordinator: Duan, Wenzhen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.