Investigating molecular markers in tumors linked to HPV
Official title: Molecular Markers for Tumors Associated with Extrachromosomal HPV
Funded at Medical College of Wisconsin · NIH-11049040 · Data updated 2026-11-12
This study is looking at how different types of HPV in cervical cancer tumors can affect treatment options, with the goal of finding better ways to help patients, especially those who may not have easy access to current care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | March 5, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $575,045 |
| NIH project number | 5R01CA279323-02 |
| Project ID | NIH-11049040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with HPV-positive cervical cancer, particularly those with eHPV tumors.
✕Less likely to help
Patients with HPV-negative cervical cancer or those without cervical cancer may not benefit from this research.
What this research studies
This research focuses on understanding the differences between tumors that contain extrachromosomal HPV (eHPV) and those with integrated HPV (iHPV). By analyzing these tumors, the researchers aim to identify distinct molecular drivers that could lead to different treatment strategies. The study will explore novel diagnostic and therapeutic approaches to improve outcomes for patients with cervical cancer, particularly in populations with limited access to current prevention methods. Patients with eHPV tumors have shown better clinical outcomes, highlighting the need for tailored treatment options.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for patients with cervical cancer.
How similar studies have gone: Other research has indicated that understanding the molecular differences in HPV-related tumors can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Ojesina, Akinyemi Ifedapo — Medical College of Wisconsin
- Study coordinator: Ojesina, Akinyemi Ifedapo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.