Investigating molecular factors influencing heart disease risk and early detection
Epigenomic and Metabolomics Determinants of Subclinical and Clinical Vascular and Myocardial Disease
This study is looking at how our genes and environment affect heart disease, especially in people at higher risk like South Asians, to find new ways to prevent and manage cardiovascular issues.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11063172 on NIH RePORTER |
What this research studies
This research aims to improve the accuracy of cardiovascular disease (CVD) risk assessments by exploring the molecular factors linked to both subclinical and clinical forms of heart disease. It employs a multi-omic approach, analyzing genetic and environmental influences on CVD, particularly focusing on how epigenetic and metabolomic markers respond to environmental factors. By understanding these molecular interactions, the study seeks to identify new pathways that contribute to heart disease, especially in populations at higher risk, such as South Asians. This could lead to better prevention and management strategies for CVD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals under 20 years of age, particularly those from South Asian backgrounds who may be at higher risk for cardiovascular diseases.
Not a fit: Patients who are not within the targeted age group or do not have risk factors for cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise risk predictions and earlier detection of cardiovascular diseases, ultimately improving patient outcomes.
How similar studies have performed: Other research has shown promise in using multi-omic approaches to understand cardiovascular disease, indicating that this method could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Sun, Yan — Emory University
- Study coordinator: Sun, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.