Investigating models of lymphoma to understand cancer development
Official title: Core 1: Lymphoma models
Funded at Weill Medical Coll of Cornell Univ · NIH-10847992 · Data updated 2026-11-12
This study is exploring different ways to understand and treat Diffuse Large B-Cell Lymphoma (DLBCL) by using special models that mimic the disease, so that we can learn how genetic changes affect cancer growth and how well treatments work, ultimately helping patients get better care.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $249,555 |
| NIH project number | 1P01CA272295-01A1 |
| Project ID | NIH-10847992 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Diffuse Large B-Cell Lymphoma or related conditions.
✕Less likely to help
Patients with other types of cancers or those not diagnosed with lymphoma may not receive direct benefits from this research.
What this research studies
This research focuses on developing and characterizing various models of lymphoma, particularly Diffuse Large B-Cell Lymphomas (DLBCL). It utilizes engineered mouse models, patient-derived tumor xenografts, and organoids to study the genetic and molecular factors that contribute to lymphoma. By integrating advanced techniques such as RNA sequencing and antibody profiling, the research aims to uncover how specific genetic defects influence cancer progression and treatment responses. Patients may benefit from insights gained through these models, which could lead to improved therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for lymphoma patients by identifying key genetic factors involved in cancer development.
How similar studies have gone: Previous research has shown success in using similar models to study cancer, indicating a promising approach for understanding lymphoma.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Inghirami, Giorgio — Weill Medical Coll of Cornell Univ
- Study coordinator: Inghirami, Giorgio
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.