Investigating Müller cell changes in age-related macular degeneration.
Muller cell activation and remodeling in AMD.
This study is looking at how special cells in the eye, called Müller cells, react to changes that happen in age-related macular degeneration (AMD), which affects vision in older adults, to help find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11012400 on NIH RePORTER |
What this research studies
This research explores the role of Müller cells in age-related macular degeneration (AMD), a condition that affects vision in older adults. The study aims to understand how these cells respond to changes in the eye associated with AMD, particularly in areas where retinal cells are lost. Researchers will analyze human donor eyes and conduct laboratory experiments to see how Müller cells interact with components like amyloid beta and oxidized lipids, which may contribute to the disease. By examining these cellular responses, the research seeks to uncover mechanisms that could lead to new treatment strategies for AMD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with age-related macular degeneration, particularly those experiencing geographic atrophy.
Not a fit: Patients with other forms of vision impairment unrelated to age-related macular degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve vision or slow the progression of age-related macular degeneration.
How similar studies have performed: Previous research has shown promising results in understanding the role of Müller cells in retinal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Edwards, Malia Michelle — Johns Hopkins University
- Study coordinator: Edwards, Malia Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.