Investigating mitochondrial dysfunction using a new mouse model
Official title: Novel Knock-in mtDNA Mouse Model to Study Mitochondrial Dysfunction
Funded at University of Rhode Island · NIH-10949480 · Data updated 2026-11-12
This study is looking at how problems with tiny parts of our cells called mitochondria might lead to diseases like Alzheimer's, using special mice to see how these issues affect their health and behavior, which could help us find new ways to treat these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rhode Island NIH-funded |
| Lab location | 1 site (Kingston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $236,250 |
| NIH project number | 1R21OD037651-01 |
| Project ID | NIH-10949480 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease or those experiencing early symptoms of cognitive decline.
✕Less likely to help
Patients with non-neurological conditions or those not affected by mitochondrial dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding how mitochondrial dysfunction contributes to various diseases, particularly Alzheimer's disease and related dementias. By creating a novel mouse model with specific mutations in mitochondrial DNA, researchers aim to explore the effects of these mutations on aging and disease progression. The study will involve observing the mice for changes in health and behavior that mimic human conditions, providing insights into potential therapeutic targets. This approach could lead to a better understanding of how mitochondrial health impacts overall well-being and disease development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease and related dementias.
How similar studies have gone: Previous research using similar mitochondrial models has shown promise in understanding age-related diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Rhode Island
Kingston, United States Active
Researchers
- Principal investigator: Ross, Jaime Marie — University of Rhode Island
- Study coordinator: Ross, Jaime Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.