Investigating mitochondrial dysfunction in Alzheimer's disease
RLIP, Mitochondrial Dysfunction in Alzheimer’s Disease
This study is looking at how a protein called RalBP1 helps protect the brain from damage in Alzheimer's disease, and it hopes to find new ways to treat the condition by learning from specially modified mice.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-10901025 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of oxidative stress and mitochondrial dysfunction in Alzheimer's disease (AD). It examines how a specific protein, RalBP1 (Rlip), contributes to the brain's defense against oxidative stress and how its absence may lead to increased oxidative damage and synaptic impairment in neurons. By studying genetically modified mice, the research aims to uncover mechanisms that could lead to new therapeutic strategies for AD. Patients may benefit from insights gained into the disease's pathology and potential new treatment avenues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at high risk due to genetic factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that may slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding oxidative stress mechanisms in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Reddy, P. Hemachandra — Texas Tech University Health Scis Center
- Study coordinator: Reddy, P. Hemachandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.