Investigating mitochondrial DNA's role in chronic kidney disease progression
Official title: The quality and quantity of mitochondrial DNA in chronic kidney disease progression
Funded at Ut Southwestern Medical Center · NIH-11231207 · Data updated 2026-11-12
This study is looking at how the tiny parts of your cells called mitochondrial DNA might influence the worsening of chronic kidney disease, and it aims to find clues that could help doctors predict kidney problems and improve treatment for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | May 20, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $687,717 |
| NIH project number | 7R01DK135873-02 |
| Project ID | NIH-11231207 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease who are willing to participate in longitudinal assessments.
✕Less likely to help
Patients with acute kidney injury or those without a diagnosis of chronic kidney disease may not benefit from this research.
What this research studies
This research focuses on understanding how mitochondrial DNA (mtDNA) affects the progression of chronic kidney disease (CKD). By measuring the quantity and quality of mtDNA in patients, the study aims to identify potential biomarkers that could predict kidney function decline. The researchers will conduct longitudinal assessments to track changes in mtDNA over time and explore the underlying mechanisms that contribute to CKD progression. This could lead to new therapeutic targets for improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and managing chronic kidney disease.
How similar studies have gone: Previous studies have shown promising results in understanding mitochondrial DNA's role in chronic kidney disease, indicating that this approach has potential for significant findings.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Li, Changwei — Ut Southwestern Medical Center
- Study coordinator: Li, Changwei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.