Investigating misfolded proteins and RNA splicing in Alzheimer's disease
Official title: Cell-type-specific and spatial proteogenomics analysis of aberrant RNA splicing and misfolded proteins in Alzheimer's related tauopathies
Funded at University of California-Irvine · NIH-11111740 · Data updated 2026-11-12
This study is looking at how certain proteins that don't fold correctly build up in the brains of people with Alzheimer's and similar conditions, using special techniques to examine brain samples from both humans and mice, with the hope of finding new ways to help treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $773,816 |
| NIH project number | 1R01AG092453-01 |
| Project ID | NIH-11111740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how misfolded proteins accumulate in the brains of individuals with Alzheimer's disease and related dementias. By using advanced techniques like spatial transcriptomics and proteogenomics, researchers will analyze brain tissues from both human patients and specially designed mouse models. The goal is to identify specific cell types that exhibit abnormal gene expression and protein accumulation, which may contribute to the progression of Alzheimer's. This study aims to uncover the molecular mechanisms behind these processes, potentially leading to new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease, improving outcomes for patients.
How similar studies have gone: Previous research has shown promise in understanding protein misfolding in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Xu, Xiangmin — University of California-Irvine
- Study coordinator: Xu, Xiangmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.