Investigating microvascular changes in Alzheimer's disease and aging
Microvascular Neuroimaging in Age-related Alzheimer's Disease and Tauopathies
This study is looking at how problems with tiny blood vessels in the brain might lead to memory loss and Alzheimer's disease in older adults, using special imaging tools to see how brain injuries affect health, and it hopes to find new ways to help people with Alzheimer's.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11091615 on NIH RePORTER |
What this research studies
This research focuses on understanding how microvascular dysfunction contributes to Alzheimer's disease and memory loss in aging individuals. Using advanced imaging techniques like dynamic contrast enhanced MRI and laser ablation mass spectrometry, the study aims to explore the effects of trauma-induced microvascular injury on brain health. By examining these relationships, the research seeks to uncover potential mechanisms that accelerate Alzheimer's-related pathology and cognitive decline. Patients may benefit from insights gained into the progression of Alzheimer's disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing memory deficits or those diagnosed with Alzheimer's disease.
Not a fit: Patients with non-age-related cognitive impairments or those without any signs of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease and related cognitive impairments.
How similar studies have performed: Previous research has shown promising results in understanding microvascular dysfunction in neurodegenerative diseases, indicating that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Hua, Ning — Boston University Medical Campus
- Study coordinator: Hua, Ning
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.