Investigating microRNAs and mitochondria as targets for stroke treatment in older adults
Official title: MicroRNAs, Mitochondria and the Blood-Brain Barrier - Therapeutic Targets for Stroke
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10992153 · Data updated 2026-11-12
This study is looking at how tiny molecules and cell energy in older stroke patients might impact the protective barrier in the brain, with the hope of finding new ways to help them recover better after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $408,058 |
| NIH project number | 5R01NS117606-03 |
| Project ID | NIH-10992153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who have experienced a stroke.
✕Less likely to help
Patients who are younger than 65 or have not experienced a stroke may not benefit from this research.
What this research studies
This research focuses on understanding how microRNAs and mitochondrial function affect the blood-brain barrier in older stroke patients. By studying the changes in these cellular components, the researchers aim to identify potential therapeutic targets that could improve outcomes for individuals who have suffered a stroke. The approach involves analyzing plasma and cerebrovascular endothelial cells from both aged stroke mice and human patients to uncover the mechanisms behind blood-brain barrier disruption. The ultimate goal is to develop effective treatments that can restore barrier integrity and enhance recovery in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery and quality of life for older stroke patients.
How similar studies have gone: Previous research has shown promise in targeting microRNAs and mitochondrial function for therapeutic interventions in stroke, indicating that this approach may yield beneficial results.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Ren, Xuefang Sophie — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Ren, Xuefang Sophie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.