Investigating metabolites in early stages of multiple myeloma
Assessment of Metabolites Among Asymptomatic Precursor and Malignant Monoclonal Gammopathies
This study is looking at how certain changes in your blood and bone marrow might help doctors tell the difference between harmless conditions and those that could lead to multiple myeloma, a type of blood cancer, so they can better manage your health if you're at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10788454 on NIH RePORTER |
What this research studies
This research focuses on understanding the metabolic changes that occur in patients with asymptomatic precursor conditions leading to multiple myeloma, a serious blood cancer. By analyzing metabolites in the blood and bone marrow, researchers aim to identify new biomarkers that can help distinguish between benign and malignant conditions. The study utilizes advanced mass-spectrometry based metabolomics to explore how these metabolites correlate with the risk of progression to multiple myeloma. This could lead to improved risk assessment and management strategies for patients at risk of developing this cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with asymptomatic plasma cell disorders such as monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM).
Not a fit: Patients with active multiple myeloma or those without any precursor plasma cell disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate identification of patients at risk for multiple myeloma, allowing for timely intervention.
How similar studies have performed: Previous research has shown promise in using metabolomics to identify biomarkers in various cancers, suggesting that this approach could be effective in this context as well.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Gonsalves, Wilson — Mayo Clinic Rochester
- Study coordinator: Gonsalves, Wilson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.