Investigating metabolic weaknesses in certain cancers
Official title: Metabolic vulnerabilities in cancers with impaired TCA cycle activity
Funded at Weill Medical Coll of Cornell Univ · NIH-10975852 · Data updated 2026-11-12
This study is looking at how certain kidney cancers use different ways to get the energy and nutrients they need to grow, and it hopes to find new treatments that can specifically target these cancers to help patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2023 |
| Project end | August 14, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,994 |
| NIH project number | 5F30CA284711-02 |
| Project ID | NIH-10975852 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with renal cell cancer, particularly those with known deficiencies in TCA cycle enzymes.
✕Less likely to help
Patients with cancers that do not exhibit impaired TCA cycle activity may not benefit from this research.
What this research studies
This research focuses on understanding how specific cancers, particularly renal cell cancers, utilize altered metabolic pathways to support their growth. By examining tumors with impaired tricarboxylic acid (TCA) cycle activity, the study aims to identify their vulnerabilities to metabolic inhibitors. The approach involves analyzing how these tumors generate essential nutrients like aspartate, which is crucial for their survival and proliferation. Patients may benefit from insights that could lead to targeted therapies for these cancer types.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for certain cancers by targeting their unique metabolic vulnerabilities.
How similar studies have gone: Previous research has shown promise in targeting metabolic pathways in cancer, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Xie, Abigail — Weill Medical Coll of Cornell Univ
- Study coordinator: Xie, Abigail
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.